Core B is designed to provide support to the projects by standardizing common methods and resources, ensuring consistency and quantitative accuracy across the Program Project. Each service of the Core is relevant to and will be utilized by each project. The goals of Core B are six fold: Specific Aim 1: To provide a centralized repository of cell lines, media, and collected serum for each project. Specific Aim 2: To perform wide-field and conformal irradiation of small animals using preclinical and clinical radiotherapy systems. Specific Aim 3: To perform multimodal imaging of small animals using preclinical systems for positron emission tomography (PET), x-ray computed tomography (CT), and bioluminescence imaging (BLI). Specific Aim 4: To perform histopathologic analysis of tissue specimens collected from experimental animal models. Specific Aim 5: To perform quantitative analysis of imaging data collected through the other Specific Aims. Specific Aim 6: To provide statistical support to the projects of the P01.